To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian ...

A new tool called PHOTON, developed by scientists at UT Southwestern Medical Center, can identify RNA molecules at their native locations within cells—providing valuable clues to where different RNA ...

New method maps RNA in cells at native locations, revealing spatial responses to signals and offering insight into disease ...

Modeling the structure and dynamics of large macromolecules remains a critical challenge. Molecular dynamics (MD) simulations are expensive because they model every atom independently, and are ...

Based on several lines of interesting data, the authors conclude that FMRP, though associated with stalled ribosomes, does not determine the position on the mRNAs at which ribosomes stall. Although ...

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

Deoxyribonucleic acid (DNA) carries the genetic information needed to sustain life via unique combinations of four different nucleobases (adenine, guanine, thymine, and cytosine) and has a ...

We introduce a melded chemical and computational approach for probing and modeling higher-order intramolecular tertiary interactions in RNA. 2′-Hydroxyl molecular interference (HMX) identifies ...