News

IEEE2d
Path Synthesis of Planar Linkage Mechanisms Using Deep Generative Models - IEEE Xplore
The problem of path generation of planar mechanisms, or determining their motion as traced by a coupler curve, has been almost exclusively met with analytical solutions, leading to high run-time and ...
Researchers uncover novel mechanism for regulating ribosome biogenesis during brain development
Ribosomes are tiny molecular machines inside all living cells that build proteins, and ribosome biogenesis is the complex, ...
Solving the mystery of an ancient enzyme could lead to new carbon capture strategies
Researchers at the University of Illinois Urbana-Champaign have discovered important new clues in the mystery of how an ...
News-Medical.Net7d
Experimental drug promotes weight loss by heating fat instead of suppressing appetite
An article published in the journal Nature Metabolism presents an experimental drug that stimulates adipose tissue cells to ...
Experimental drug holds promise for controlling weight and blood sugar
An article published in the journal Nature Metabolism presents an experimental drug that stimulates adipose tissue cells to ...
BMJ7d
Continuation versus discontinuation of aspirin-based antiplatelet therapy for perioperative bleeding and ischaemic events in adults undergoing neurosurgery: protocol for a ...
Inclusion criteria: Adults (18 years old or older) taking antiplatelet drugs for at least 2 weeks; scheduled for elective or emergency neurosurgery under general anaesthesia (craniotomy, spinal cord ...
as.com15d
The painkiller that changed the world: Aspirin’s surprising journey through history
Aspirin was first introduced in 1896 by the German pharmaceutical manufacturer Bayer after being discovered by one of their researchers, chemist Felix Hoffmann (1868-1946). Box – container.
ahajournals.org20d
American Heart Association/American College of Cardiology Foundation Guide to Warfarin Therapy | Circulation - AHA/ASA Journals
Drugs such as aspirin, 57 nonsteroidal antiinflammatory drugs, 58 penicillins ... and in very high doses impair synthesis of vitamin K–dependent clotting factors. 57,60,62 The risk of major bleeding ...
C&EN20d
Synthesis, Antifungal Activity, and Potential Mechanism of Natural Product Pogostone Derivatives Containing an Acylhydrazone Scaffold
The current study designed and synthesized a series of acylhydrazone derivatives based on the natural product pogostone. Among them, compound 2a15 exhibited potent fungicidal activity against Valsa ...
C&EN24d
Nanosized Aspirin-Arg-Gly-Asp-Val: Delivery of Aspirin to Thrombus by the Target Carrier Arg-Gly-Asp-Val Tetrapeptide | ACS Nano - ACS Publications
Resistance and nonresponse to aspirin dramatically decreases its therapeutic efficacy. To overcome this issue, a small-molecule thrombus-targeting drug delivery system, aspirin-Arg-Gly-Asp-Val (A-RGDV ...
Nature24d
Duration of high-dose aspirin therapy does not affect long-term coronary artery outcomes in Kawasaki disease | Pediatric Research - Nature
High-dose aspirin (HDA) is used with intravenous immunoglobulin (IVIg) in Kawasaki disease (KD). Practice regarding HDA varies, and it is unclear whether HDA duration affects the long-term course.
ascopubs.org27d
Aspirin as secondary prevention for colorectal cancer liver metastases (ASAC): A multicenter, randomized, double-blind, placebo-controlled, phase 3 trial.
The probability of surviving past 36 months was 76.1% in the aspirin group and 84.9% in the placebo group, with an overall survival HR of 1.60 (95% CI 0.99–2.61, p=0.057) in favor of the placebo.