Open Heart

Hypothyroidism in spontaneous coronary artery dissection: presentation, clinical and angiographic findings, management and outcomes

Background Hypothyroidism has been suggested as a predisposing and prognostic factor in patients with spontaneous coronary ...
BMJ Open

Mental health in the moment: protocol for an accelerated cohort measurement burst study of adolescent mental health

Introduction Adolescence is a key period of development for mental health; however, little is known about how (cumulative) daily life experiences impact long-term mental health development in this ...

Merck’s Enlicitide Decanoate, an Investigational Oral PCSK9 Inhibitor, Significantly Reduced LDL-C in Adults with Heterozygous Familial Hypercholesterolemia (HeFH) in Phase 3 ...

Merck (NYSE: MRK), known as MSD outside of the United States and Canada, today announced the first presentation of results from the pivotal Phase 3 CORALreef HeFH trial demonstrating that treatment ...

Merck’s Enlicitide Decanoate, an Investigational Oral PCSK9 Inhibitor, Significantly Reduced LDL-C in Phase 3 CORALreef Lipids Trial

Merck (NYSE: MRK), known as MSD outside of the United States and Canada, today announced the first presentation of results from the pivotal Phase 3 CORALreef Lipids trial demonstrating that treatment ...
Open Heart

Thrombolysis in non-ST-elevation myocardial infarction: systematic review and meta-analysis of randomised controlled trials

Background Guidelines strongly recommend reperfusion therapy, including thrombolysis and percutaneous coronary intervention, ...
BMJ Open

Effectiveness of on-demand acceptance and commitment training for burnout and well-being in Japanese medical students: protocol for a nationwide randomised controlled trial ...

Introduction Burnout and reduced well-being are highly prevalent among Japanese medical students during clinical training. Scalable, evidence-based interventions are urgently needed. This protocol ...
EurekAlert!

LDL cholesterol improved among veterans in program with health coaches, other resources

After 24 months, 34% of veterans who have heart and blood vessel disease and high cholesterol in a quality improvement program that included health care coaches and other resources had improved ...
EurekAlert!

Investigational daily pill lowered bad cholesterol as much as injectables

For people who have experienced a heart attack or stroke, or who are at high risk of one and need further cholesterol lowering, a new daily pill may be a more convenient yet similarly effective option ...
Gut

Engineered virus-hunter vaccine overcomes HBV immune tolerance

Background Globally, an estimated 296 million individuals live with chronic hepatitis B virus (HBV) infection, carrying ...

Elicio Therapeutics Reports Robust, Cytolytic mKRAS-Specific T Cell Responses Across Diverse Patient HLA in Ongoing Phase 2 AMPLIFY-7P Trial of ELI-002 7P and New ELI-004 ...

SITC abstracts highlight updated immunogenicity results from the Phase 2 AMPLIFY-7P trial of ELI-002 7P and preclinical data on the use of ...
The New England Journal of Medicine

Oral Icotrokinra for Plaque Psoriasis in Adults and Adolescents

Icotrokinra, a targeted oral peptide that selectively binds the interleukin-23 receptor, is under investigation for the ...
gut.bmj

A20-mediated KEAP1 ubiquitination orchestrates hepatocyte ferroptosis to ameliorate autoimmune hepatitis

Background Autoimmune hepatitis (AIH) is characterised by death of hepatocytes and chronic inflammation. Patients with deleterious variants in A20 are identified with AIH presentations and immune ...