Both Lamprecht and Koul worked at Johnson & Johnson when the project began. Although there is a human pathway for de novo purine biosynthesis, JNJ-6640 is highly selective for PurF in M. tuberculosis.

Cholesterol is a key component of the plasma membrane and also plays important roles in signaling (Liu et al, 2023). The de novo cholesterol synthesis pathway is a complex, multi-step process in which ...

Lanthipeptides are a family of ribosomally synthesized peptides that have crucial biological functions. However, due to their complicated structures, the total synthesis of lanthipeptides is ...

“AlphaDesign represents a new level of control in computational biology: the ability to generate new proteins with measurable, targeted function. This work demonstrates that AI can go beyond ...

Paracetamol, also known as acetaminophen, is widely used to treat pain and fever. It is produced from molecules derived from ...

Merging synthetic organic chemistry and biotechnology, researchers have engineered Escherichia coli that can synthesize small ...

Researchers at the ICN2 and the UAB have developed a novel strategy to obtain different types of organic molecules by ...

A University of California, Riverside-led team has made an advance in the basic understanding of Plasmodium falciparum, the parasite responsible for the deadliest form of human malaria, that could ...

LEWES, Del., June 18, 2025 /PRNewswire/ -- The Global Oligonucleotide Synthesis Market Size is projected to grow at a CAGR of 10.49% from 2024 to 2031, according to a new report published by ...

Proteins are the workhorses of biology. They perform virtually every important function in living organisms. They store, copy and protect our DNA, digest food to give us energy, and harness this ...

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The emergence of biomolecules on the primordial Earth represents a pivotal scientific question for understanding the origin of life. Recent studies show that compounds containing nitrogen–oxygen bonds ...