ATR activates mTORC1 by increasing phosphorylation and expression of the de novo cholesterol synthesis enzyme lanosterol synthase in cancer cells. While ... Buj R, Wang H, Wang J, Cole AR, Uboveja A, ...

Background: Mycophenolate mofetil (MMF) inhibits IMPDH and disrupts de novo purine synthesis which is preferred by glioblastoma (GBM) whilst normal brain prefers resource efficient salvage pathway. A ...

This enabled the de novo synthesis of lariciresinol diglucoside through over 40 enzymatic reactions. ... Researchers achieve de novo biosynthesis of plant lignans using synthetic yeast consortia.

In the absence of genotoxic treatment, H3K27M-expressing cells have higher relative activity of de novo synthesis and apparent lower activity of purine salvage demonstrated via stable isotope tracing ...

Background: Proliferation of vascular smooth muscle cells (VSMCs) is a hallmark of arterial diseases, especially in arterial restenosis after angioplasty or stent placement. VSMCs reprogram their met ...

The de novo purine synthesis route involves several different enzymes, each of which is crucial to the process. Thus, some scientists started to question whether there was anything that organisms ...

Chinese scientists achieve de novo artificial synthesis of hexoses from CO2 0 Comment(s) Print E-mail Xinhua, August 17, 2023. Adjust font size: ...

TIANJIN, Aug. 16 (Xinhua) -- Chinese scientists have developed an artificial method of synthesizing hexoses from carbon dioxide (CO2) in a laboratory environment -- a key step in the global ...

Ansa Biotechnologies, Inc., a pioneer of next-generation DNA synthesis, today announced the successful de novo synthesis of the world's longest DNA oligonucleotide ever reported to be produced in a ...