Lanthipeptides are a family of ribosomally synthesized peptides that have crucial biological functions. However, due to their complicated structures, the total synthesis of lanthipeptides is ...

By designing proteins de novo—from scratch—scientists can more efficiently create novel therapeutics tailored for specific biological functions. In a new study, ...

Here we describe the total chemical synthesis of a 312-residue chaperone-dependent protein (DapA) in natural (l-) and mirror-image (d-) forms, the longest fully synthetic proteins yet reported. Using ...

ATR activates mTORC1 by increasing phosphorylation and expression of the de novo cholesterol synthesis enzyme lanosterol synthase in cancer cells. While ... Buj R, Wang H, Wang J, Cole AR, Uboveja A, ...

Although many researchers have reported that copper chloride is an important catalyst that generates relatively large amounts of dioxins in heat experiments involving model fly ash, details on the ...

Background: Mycophenolate mofetil (MMF) inhibits IMPDH and disrupts de novo purine synthesis which is preferred by glioblastoma (GBM) whilst normal brain prefers resource efficient salvage pathway. A ...