Fifty years of outstanding neuroscience research studies have revealed many secrets of how drugs of abuse affect and change ...

Working with data from the Fred Hutch Cancer Center, and the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO ...

Children exposed to gestational diabetes in utero with a specific variation of a common gene are at a higher risk of becoming overweight or obese during childhood, according to a new study by ...

A research team has developed a new class of compounds that effectively inhibit both wild-type CDK9 and its drug-resistant mutant form, offering a promising strategy for treating hematological ...

The objective of this study was to characterize the impact of the rs1695 polymorphism of GSTP1 in women infected by high-risk human papillomavirus (HR-HPV) in Ouagadougou, Burkina Faso. Methods: ...

In 2007, the US Food and Drug Administration (FDA) approved eculizumab (Soliris ®), a recombinant humanized monoclonal antibody, for the treatment of paroxysmal nocturnal hemoglobinuria (PNH). Beyond ...

Mandal, R.K., et al. (2019) Association of MBL2 Gene Polymorphisms with Pulmonary Tuberculosis Susceptibility Trial Sequence Meta-Analysis as Evidence. Infection and Drug Resistance, 12, 185-210.

Amyloid formation is involved in widespread health conditions such as Alzheimer’s disease, Parkinson’s disease, and type-2 diabetes. Amyloid fibrils have a similar cross-β architecture, but fibrils ...

Drug Ref. n Population Polymorphism(s) Results; Cyclosporine [10] 106: 100% Caucasian: CYP3A5 MDR1 (ABCB1) T-129C, C1236T, G2677(T,A), C3435T: No difference observed for cyclosporine and any ...

Introduction Clopidogrel is a P2Y 12 inhibitor that has become a mainstay treatment following percutaneous intervention with drug-eluting stent placement to decrease restenosis and its potential ...

The Food and Drug Administration on Tuesday approved a new drug for Alzheimer’s disease, the latest in a novel class of treatments that has been greeted with hope, disappointment and skepticism ...