The total synthesis and structural characterization of the MHCII-associated p41 invariant chain fragment (P41icf) is described. P41icf plays a crucial role in the maturation of MHC class II molecules ...

In this segment, the experts discuss the selection criteria among four available JAK inhibitors—ruxolitinib, fedratinib, pacritinib, and momelotinib—for myelofibrosis treatment. Dr. Rampal notes that ...

We demonstrate that substitutionally inert octahedral metal complexes, such as the iridium (III) carbene complex (1a), provide a useful source of potent inhibitors for unexplored oncogenic protein ...

Including PD-L1 inhibitors, this category had estimated sales of $48.7 billion in 2024. 5 Some analysts believe that figure could triple in the next decade. 5,6 ...

Purpose TLR7 and TLR8 (TLR7/8) are members of the Toll-Like Receptor family that recognize single strand RNA. Activation of TLR7/8 within immune cells elevates pro-inflammatory cytokines and type ...

Cathepsin S (CTSS), a lysosomal cysteine protease predominantly expressed in immune cells, governs inflammatory and immunological cascades through proteolytic activity. Beyond maintaining lysosomal ...

WD repeat domain 5 (WDR5) is a member of the WD40-repeat protein family that plays a critical role in multiple processes. It is also a prominent target for pharmacological inhibition in diseases such ...

Credit: PeopleImages.com – Yuri A/Shutterstock. Bayer subsidiary Vividion Therapeutics has secured exclusive worldwide rights to develop and commercialise VVD-214, the Werner helicase (WRN) covalent ...