Prostate cancer is one of the most common malignancies in men globally. Hormonal therapies targeting the androgen–androgen ...

In vitro acetylcholinesterase inhibition assay - In this work, 27 crude methanol plant extracts were examined for their AChE inhibitory activities at concentrations of 1000, 100, and 10 mg/l and were ...

We have developed a new assay, using ion mobility-mass spectrometry, capable of both rapidly detecting inhibitor binding and classifying the resultant kinase binding modes. Here, we demonstrate the ...

In target-based drug discovery, quantification of target engagement is required to build structure–activity relationships and develop a potent clinical candidate. Target engagement data also provides ...