The situation normalises progressively, however, with the increasing number of copies of the four histone genes produced: "Flies with twelve copies of the histone gene cluster ultimately survive ...

The accurate distribution of chromosomes in an oocyte is essential for the correct transmission of genetic information to the ...

Histone gene transcription is downregulated after DNA synthesis is completed, but how cells terminate histone gene transcription has been unknown. A new study uncovers that phosphorylation of ...

"The histone H3 genes we wanted to change are clustered in one location in the genome of a fruit fly, without other essential genes in the cluster, so they can all be removed at once and replaced ...

Humans have two clusters of histone genes, ... Cajal bodies often associate with histone gene clusters, so this finding provided an intriguing link between cyclin E–CDK2 and histone genes.

In their upcoming G&D paper, Dr. Robert Tjian and colleagues reveal how histone gene expression is differentially regulated during Drosophila development. The researchers demonstrate that ...

Scientists refer to this process as "gene silencing". "The histone modifications can intervene in the control of gene activity in this way and, as a result, complement the genetic code," explains ...

A 2022 paper in the Journal of the American Chemical Society noted that the histone-gene interplay “may provide novel insight” into the development of neurodegenerative diseases such as dementia.

(PhysOrg.com) -- The development of blood from stem cell to fully formed blood cell follows a genetically determined program. When it works properly, blood formation stops when it reaches maturity.

Researchers investigate different epigenetic alterations that regulate gene expression, including histone modifications and DNA methylation. iStock , VectorMine Since its discovery in the early 1940s, ...

The acetyl group returned to the histone molecule and the mice’s learning and memory performance became similar to that of 3-month-old mice. Post-mortem brains ...

How do you get a two-metre-long DNA thread into the cell nucleus? By winding it into a ball, of course! The DNA is wound around proteins known as histones, becoming 50,000 times shorter as a result.