How alterations in cell metabolism translate into specific developmental gene programs remains a major question. This study ...

Epigenetic reprogramming holds promise for reversing aging, addressing cellular aging mechanisms and paving the way for ...

Citrullination, a transformative protein post-translational modification, is gaining recognition for its wide-ranging impact on cellular function and human disease.

Zhang et al. present important findings that reveal a new role for TET2 in controlling glucose production in the liver, showing that both fasting and a high-fat diet increase TET2 levels, while its ...

This study provides valuable findings on the role of site-specific DNA methylation changes during spermatogenesis and their contribution to paternal epigenetic inheritance. The study proposes that ...

School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, China ...

School of Public Health, Food Safety and Health Research Center, Guangdong Provincial Key Laboratory of Tropical Disease Research, Southern Medical University, Guangzhou 510515, China ...

Contributed by Jian-Kang Zhu; received November 8, 2024; accepted March 7, 2025; reviewed by Cao Xu and Ramin Yadegari ...

One function of histone modifications is to make DNA more or less accessible for transcription. Heterochromatin is highly ... they regulated that way,” remarked Cosgrove. “Generally, methylation at ...

is correlated with the inhibition of gene transcription. Ngollo and collaborators investigated genome-wide H3K27me3 histone methylation distribution using chromatin immunoprecipitation (ChIP) and ...