Paired drugs kill precancerous colon polyps, spare normal tissue Date: March 29, 2010 Source: University of Texas M. D. Anderson Cancer Center Summary: ...

The Wyss team showed that the colon epithelium in the chip is fully polarized with distinct markers restricted to its lumen-exposed, mucus-secreting side and its opposite membrane-binding side.

Researchers have discovered a gene that appears to allow colon tumors to spread to other parts of the body, ... the scientists were also able to compare PRL-3 expression in normal epithelium, ...

The Wyss team showed that the colon epithelium in the chip is fully polarized with distinct markers restricted to its lumen-exposed, mucus-secreting side and its opposite membrane-binding side.

Senescent fibroblasts that accumulate in colon tissues increase colon cancer risk and promote colon cancer formation via a senescence associated secretory phenotype (SASP). This pro-tumorigenic tissue ...

As incomplete intestinal metaplasia is associated with higher risk of gastric cancer, its lower CDX2 expression compared with that in complete intestinal metaplasia and normal colon epithelium ...

We then discuss the role of SCs in homeostasis of normal colonic epithelium, and mechanisms by which dysregulation of crypt mechanisms can lead to initiation and progression of ... Epithelial colon ...

Epithelial cells in the colon mainly use microbial fermentation products as energy sources. Here Okada et al. find that lactate produced by commensal Lactobacillus murinusregulates colonic ...

The regulatory protein c-MYC plays an important role in promoting the development of many types of tumors. c-MYC is a transcription factor that controls the activity of large numbers of genes ...

A team of researchers discovered mutations that occur during normal aging of human tissues that are induced by the jumping gene of ‘long interspersed nuclear element-1’ (L1).

Kaestner's group had earlier published research on a transcription factor called Foxl1 that is also expressed in the colon, but in a different layer of cells, adjacent to the epithelium, called ...