The Synthetic Human Genome, or Syn HG, a project launched on June 26th, aims to change that. Funded partly by Wellcome, a ...

That's when we discovered the cancer has a backup plan." This “backup plan” involves the protein p53. The current study showed that although inhibition of GCN2 depleted amino acids used in purine ...

4 Department of Geriatric Medicine, Shenzhen Longhua District Central Hospital, Shenzhen, China The core of tumor cell metabolism is the management of energy metabolism due to the extremely high ...

We systematically analyzed the biochemical studies in which enzyme activities related to purine or pyrimidine nucleotide metabolism were reported for the currently genome-sequenced mollicutes, which ...

Here, we determined the effect of exogenous purine nucleotide administration on purine nucleotide metabolism in the brains of heroin-dependent rats. Heroin was administrated in increasing doses for 9 ...

EMERYVILLE, Calif.-- (BUSINESS WIRE)-- Ansa Biotechnologies, Inc., a pioneer of next-generation DNA synthesis, today announced the successful de novo synthesis of the world’s longest DNA ...

Proliferative cells require increased nucleotide synthesis for DNA replication and RNA production to meet the enhanced demand for protein synthesis during cell proliferation. 4 To obtain adequate ...

ATIC knockdown decreases de novo purine metabolism-mediated nucleotide synthesis in proliferative vascular smooth muscle cells. A, Normalized peak areas of 15 N-labeled purine intermediates, as ...

Adenylosuccinate lyase (ADSL) functions in de novo purine synthesis (DNPS) and the purine nucleotide cycle. ADSL deficiency (ADSLD) causes numerous neurodevelopmental pathologies, including ...

Interestingly, nucleotide biosynthesis is itself an energetically demanding process, costing a cell 8 ATP molecules to synthesize one adenine molecule from one glucose molecule. Indeed, cells employ a ...

Nucleotide synthesis during cell division During quiescence, which is a temporary cell state of rest that occurs during the G0 or G1 phases of cell division, mammalian cells will contain the ...