The authors add, "During dexterous licking, a climbing fiber induced suppression of Purkinje cells in the lingual vermis inhibited the forces that would otherwise retract the tongue, resulting in ...

Summary: Researchers studying marmosets discovered that Purkinje cells in the cerebellum help regulate tongue movement by signaling when to stop as the tongue nears its target. These cells were highly ...

Human cells have a complex DNA repair system involving over 500 crucial genes. By analyzing interactions among these genes, researchers identified new potential targets for cancer therapy.

Tim-3 is an immune checkpoint molecule involved in immunity and inflammation recently linked to late-onset Alzheimer's disease (AD), but its role in the brain was unknown until now. In a paper ...

Summary: A new study reveals that microRNAs—tiny regulators of gene expression—play a crucial role in shaping Purkinje cells, rare brain neurons linked to movement and neurodevelopmental disorders.

Methods: The effect of the specific Nav1.8 blocker, A-803467, on action potential was recorded from epicardial, mid-myocardial (M cells) and Purkinje tissue slices isolated from the canine left ...

Purkinje cell (PC) hypoexcitability could play a role in Friedreich ataxia (FA) pathophysiology, according to a recently published study in The Cerebellum. Current research increasingly suggests that ...

Nature Research Intelligence Topics enable transformational understanding and discovery in research by categorising any document into meaningful, accessible topics. Read this blog to understand ...

“And also trying to unravel a little bit of the cellular mechanisms that were at play here.” To model ataxia, the team selectively silenced Purkinje cells in mice, which caused ataxia-like motor ...

The function of a feedback inhibitory circuit between cerebellar Purkinje cells and molecular layer interneurons (MLIs) was defined by combining optogenetics, neuronal activity recordings both in ...

The laminar organization of the monkey EC was systematically examined and compared with that of the rodent EC by using immunohistochemistry for molecular markers which have been well characterized in ...