Mechanistic discrepancies between species highlights the limitations of mouse models in advancing STING inhibition drugs for various diseases.

Researchers have long focused on the STING (Stimulator of Interferon Genes) pathway as a way to harness the immune system's ...

Genes tied to inflammation were dialed down, while genes linked to healthy brain signaling and memory were turned up. In other words, blocking STING not only stopped damage—it helped restore ...

Two key genes, TPO and DUOX2, play essential roles in thyroid hormone biosynthesis, with mutations, particularly in DUOX2, being strongly associated with hypothyroidism due to impaired hormone ...

A variety of gene therapy approaches have been evaluated for the treatment of follicular cell-derived and medullary thyroid cancer, including corrective gene therapy (p53 restoration, expression ...

The gene changes that lead to thyroid cancer are usually acquired rather than inherited. This means the changes occur due to something in a person’s environment, such as radiation exposure ...

Among adults with thyroid cancer, those with hypoparathyroidism after a thyroidectomy may have increased risk for several complications such as diabetes, hypertension and dyslipidemia, researchers ...

After rising over a 35-year period, thyroid cancer incidence in the U.S. plateaued from 2010 to 2019, according to findings published in The Lancet Diabetes & Endocrinology. In a retrospective ...

People may have an increased risk of thyroid cancer if they have a family history of the disease or a rare genetic disorder called multiple endocrine neoplasia type 2, or MEN2, Siegel said.

Additionally, targeted therapies have been developed to address specific genetic mutations associated with thyroid cancer, offering hope for patients with previously difficult-to-treat variants.

However, she noted, the fact that these male thyroid cancer survivors have no difference in their long-term fertility could argue against freezing, particularly since conceiving when euthyroid and ...