eLife1d
Synchronous processing of temporal information across the hippocampus, striatum, and orbitofrontal cortex
This study examined the important question of how neurons code temporal information across the hippocampus, dorsal striatum, and orbitofrontal cortex. Using a behavioral task in the rat that requires ...
eLife1d
Molecular Feature-Based Classification of Retroperitoneal Liposarcoma: A Prospective Cohort Study
Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory for Digestive Health, National Clinical Research Center for Digestive Disease, Beijing ...
eLife1d
Volume electron microscopy reveals unique laminar synaptic characteristics in the human entorhinal cortex
The entorhinal cortex (EC) plays a pivotal role in memory function and spatial navigation, connecting the hippocampus with the neocortex. The EC integrates a wide range of cortical and subcortical ...
eLife2d
Early Diagnosis and Prognostic Prediction of Colorectal Cancer through Plasma Methylation Regions
The methylation of plasma cell-free DNA (cfDNA) has emerged as a valuable diagnostic and prognostic biomarker in various cancers including colorectal cancer (CRC). Currently, there are no biomarkers ...
eLife2d
PEBP1 amplifies mitochondrial dysfunction-induced integrated stress response
A thermal stability-based proteomic analysis identifies cytoplasmic PEBP1 as a mediator of mitochondrial dysfunction-induced stress response, highlighting its potential role in cellular adaptation ...
eLife3d
Special Issue: Reproductive health
The articles in this special issue highlight the diversity and complexity of research into reproductive health, including the need for a better understanding of the fundamental biology of reproduction ...
eLife3d
Citalopram exhibits immune-dependent anti-tumor effects by modulating C5aR1 + TAMs and CD8 + T cells
This important study provides solid evidence to support the anti-tumor potential of citalopram, originally an anti-depression drug, in hepatocellular carcinoma (HCC). In addition to their previous ...
eLife3d
Disentangling acute motor deficits and adaptive responses evoked by the loss of cerebellar output
Cerebellar patients exhibit various motor impairments, but the sequence of primary and compensatory processes leading to these deficits remains unclear. To investigate this, we reversibly blocked ...
eLife3d
A VgrG2b fragment cleaved by caspase-11/4 promotes Pseudomonas aeruginosa infection through suppressing the NLRP3 inflammasome
This valuable study on Pseudomonas subverting host immunity identifies a new immune evasion strategy. There is solid evidence for the cleavage of VgrG2B by Caspase 11 and the generation of fragments ...
eLife3d
Developmental oligodendrocytes regulate brain function through the mediation of synchronized spontaneous activity
In this valuable manuscript, authors ablate cerebellar oligodendrocytes during postnatal development and show that synchrony of calcium transients in Purkinje neurons and behaviours are affected even ...
eLife3d
Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome
Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, public reviews, and a provisional response from the authors. In this manuscript, ...
eLife3d
Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome
The manuscript represents a fundamental advance in designing peptide inhibitors targeting Cdc20, a key activator and substrate-recognition subunit of the APC/C ubiquitin ligase. Supported by ...