Lupus Science & Medicine

Serum lipidomic and metabolomic signatures link epicardial adipose tissue to cardiovascular diseases in SLE: a post-hoc analysis

Objective Cardiovascular diseases are a leading cause of morbidity and mortality in SLE. In this target population, ...
Lupus Science & Medicine

Cells’ survival pattern of kidney macrophages and epithelial cells in lupus nephritis is influenced by glycolysis

Objective Macrophages and kidney cell pyroptosis/ferroptosis could play an important role in the pathogenesis of lupus ...
Lupus Science & Medicine

Adverse childhood experiences are associated with disease and mental health outcomes in childhood-onset SLE

Objective To investigate the relationship between adverse childhood experiences (ACEs) and health outcomes in childhood-onset ...
lupus.bmj

Lupus Science & Medicine®

is a global, peer-reviewed, open access lupus journal from LFA, publishing papers on all aspects of lupus and related diseases.
lupus.bmj

Biomarker-stratified efficacy and safety of biologics in systemic lupus erythematosus: a systematic review and meta-analysis

Objective Biologics for systemic lupus erythematosus (SLE) demonstrate variable treatment responses across trials. We evaluated baseline biomarkers as predictors of response to guide personalised ...
lupus.bmj

Sex-based clinical and immunological differences across lupus erythematosus subtypes: a cross-sectional multicentre study from China

Objective To investigate sex-related differences in clinical and immunological features across lupus erythematosus (LE) subtypes. Methods This cross-sectional analysis, based on the Lupus ...
lupus.bmj

Measurements of urinary biomarkers at 2 years following a lupus nephritis flare are associated with subsequent renal outcomes

Objective To determine if the levels of five urinary biomarkers (UBs), including cluster of differentiation 163 (CD163), monocyte chemoattractant protein-1 (MCP-1), adiponectin, soluble vascular cell ...
lupus.bmj

Validation of proposals for definitions of moderate and severe disease activity in SLE: impact on flares, quality of life, damage accrual, hospitalisations and mortality

Introduction Accurate assessment of disease activity in SLE is crucial but challenging due to its varied clinical manifestations and severity. Current tools like the SLE Disease Activity Index (SLEDAI ...
lupus.bmj

Complete blood count-derived biomarkers as indicators of systemic lupus erythematosus activity: a cross-sectional comparative study

Background SLE is a chronic autoimmune disease with heterogeneous manifestations. This study evaluated the discriminative value of complete blood count-derived biomarkers, including ...
lupus.bmj

Characterisation of systemic lupus erythematosus associated with immune checkpoint inhibitors: a pharmacovigilance study using FAERS database

Objectives SLE associated with immune checkpoint inhibitors (ICIs) is rare, and a comprehensive profile of ICI-induced SLE remains poorly characterised. This study aimed to explore the potential ...
lupus.bmj

Glycosylation of anti-dsDNA IgG correlates with organ involvement in treatment-naïve patients with systemic lupus erythematosus

Objective This study aimed to leverage machine learning algorithms to explore the relationship between anti-double-stranded DNA (anti-dsDNA) immunoglobulin G (IgG) glycosylation and the degree of ...
lupus.bmj

Pulmonary arterial hypertension in systemic lupus erythematosus: identification of risk factors and haemodynamics characteristics in a multicentre retrospective cohort

Objectives The aim of our work was to identify specific patterns in clinical features and nailfold capillary changes that may help in screening for pulmonary arterial hypertension (PAH) in patients ...