Proceedings of the National Academy of Sciences (PNAS)

Learn from the blame game when AI causes harm

This case illustrates a recurring dilemma in AI governance. As large language models (LLMs) and autonomous decision-making ...
PNAS

Danger at the border: Rac turns nibblers into murderers

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PNAS

Retraction for Liaki et al., A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance

The editors are retracting this article due to an undisclosed relevant competing interest at the time of submission. NAS Member Contributing author, Mariano Barbacid, and two coauthors, Vasiliki Liaki ...
PNAS

MANY-ELECTRON THEORY OF ATOMS AND MOLECULES

MANY-ELECTRON THEORY OF ATOMS AND MOLECULES Note: The article usage is presented with a three- to four-day delay and will update daily once available. Due to ths delay, usage data will not appear ...
PNAS

FORMATION AND DETECTION OF RNA-DNA HYBRID MOLECULES IN CYTOLOGICAL PREPARATIONS

A technique is described for forming molecular hybrids between RNA in solution and the DNA of intact cytological preparations. Cells in a conventional tissue squash are immobilized under a thin layer ...
PNAS

In This Issue

Foraging honey bees (Apis mellifera) returning to the hive can perform waggle dances to communicate the direction and distance of a food source to nestmates. The waggle dance is considered a one-way ...
PNAS

Correction for Zhu et al., SETD2-mediated H3K14 trimethylation promotes ATR activation and stalled replication fork restart in response to DNA replication stress

Correction for “SETD2-mediated H3K14 trimethylation promotes ATR activation and stalled replication fork restart in response to DNA replication stress,” by Qian Zhu, Qiaoyan Yang, Xiaopeng Lu, Hui ...
PNAS

Structural innovation and flexibility in plant chemical defenses

Structural innovation and flexibility in plant chemical defenses ...
PNAS

Microheterogeneous singlet oxygen generation at air–water interfaces

Singlet oxygen (1 O 2) drives key photochemical reactions in the atmosphere and natural waters, yet its spatial distribution in multiphase systems remains unexplored. Here, we reveal strong microscale ...
PNAS

In This Issue

MethylScan enables cell-free DNA methylome sequencing and noninvasive and simultaneous detection of multiple diseases. Image credit: Shakil Ahmad (artist). Human remains from archaeological sites in ...
PNAS

Negative design enables cell-free expression and folding of designed transmembrane β-barrels

Membrane proteins (MPs) are essential to biology and biotechnology yet designing them from scratch remains challenging. Using synthetic transmembrane β-barrels and a cell-free expression system with ...
PNAS

Proton-activated chloride channel 1 is essential for innate host defense against bacterial sepsis

Bacterial sepsis remains a major global health burden. Here, we report an essential role for the recently discovered acid-sensitive chloride channel, Proton-activated chloride channel 1 (PACC1) ...