ApoE and Tweety Homolog 2—Proteins that Flock Together?
Jul 11, 2025 · The role of ApoE has been well-studied outside of the cell, but what happens after it’s let inside? Scientists led by Raimund Dutzler, University of Zurich, have identified Tweety homologue 2 …
APP C-Terminal Fragments Stifle Calcium Flow from ER to Lysosomes
Apr 27, 2024 · These results indicate a delay in endosome-to-lysosome maturation, with lysosomes failing first. Calcium levels in lysosomes also fell by 30 percent in the 24 hours after DAPT. Bretou …
When SORL1 Dimerizes in Endosomes, Retromers Recycle APP Faster
Feb 2, 2023 · Indeed, they found that SORL1 dimers in the endosome existed almost entirely in complex with retromer. How might SORL1 dimerization influence the recycling and processing of APP? To …
Toward an AD CRISPR Therapy: Tweaking APP Terminus Cuts Plaque
Jun 27, 2024 · Researchers led by Subhojit Roy at the University of California, San Diego, used CRISPR gene editing to remove a six-residue motif that targets APP to the endosome, where β-secretase, …
Partners in Crime: APP Fragment and Endosomal Protein Impair ...
Jul 21, 2015 · The small GTPase rab5, which switches on in AD, regulates endosome trafficking and drives these changes (see Stenmark, 2009; Cataldo et al., 2008). Nixon reported that the β-CTF …
Interactions between TTYH2 and APOE facilitate endosomal lipid …
Jul 11, 2025 · An interesting avenue for future research is to better characterize the interactions that ApoE undergoes as the endosome matures and fuses with the lysosome. Do other proteins take …
Endosomal Dysfunction Induced by Directly Overactivating Rab5 ...
Jan 13, 2021 · A strength of the paper is that the authors go on to use the new mouse model to explore different pathological consequences for increased Rab5a activation and endosome dysfunction on …
Might SORL1 Bind Tau in Glia, Fuel Its Aggregation?
May 4, 2024 · That works for the type 1 integral membrane proteins that form its usual cargo, because such proteins, as with SORL1, will be endocytosed and the two will therefore encounter each other in …
Alzheimer's-related endosome dysfunction in Down syndrome is Abeta ...
Jan 26, 2010 · It is established that overexpression of APP, such as in Down syndrome, leads to endosome dysfunction. The article by Jiang et al. (1) now elegantly shows that the endosomal …
Accumulation of APP C-terminal fragments causes endolysosomal ...
Apr 27, 2024 · The authors convincingly show that the inhibition, or loss, of γ-secretase activity results in endolysosomal dysfunction, such as early endosome enlargement, changes in lysosomal calcium, …