KRAS - Wikipedia
KRAS acts as a molecular on/off switch, using protein dynamics. Once it is allosterically activated, it recruits and activates proteins necessary for the propagation of growth factors, as well as other cell …
What’s new in KRAS mutation research? - MD Anderson Cancer Center
The most frequently mutated of these oncogenic driver genes, called KRAS, is associated with some of the most fatal cancer types: lung, pancreatic and colorectal cancers.
KRAS “Cracked Open”: Karmanos Researchers ... - McLaren Health Care
5 days ago · A major new review published in the high-impact Nature journal Signal Transduction and Targeted Therapy (impact factor >50) is reshaping the conversation around KRAS, one of the most …
The evolving landscape of RAS-targeted therapies - Nature
Dec 10, 2025 · The initial discovery of an inhibitor of KRAS G12C revolutionized the KRAS field. Since then, more-potent G12C-specific inhibitors, newer allele-specific inhibitors and combinations based …
KRAS Mutations in Solid Tumors: Characteristics, Current Therapeutic ...
Kristen rat sarcoma (KRAS) gene is one of the most common mutated oncogenes in solid tumors. Yet, KRAS inhibitors did not follow suit with the development of targeted therapy, for the structure of …
Hyperactive KRAS mutation triggers cell death in the pancreas
6 days ago · The new study, published in Cancer Research Communications, showed that a rare version of the KRAS gene hyperactivates a key cancer-driving pathway so intensely that pancreatic …
Exploring KRAS: A precision approach in oncology - MSD
Jul 22, 2025 · KRAS is one of the most frequently mutated oncogenes found in cancer. In healthy cells, KRAS serves as an on-off switch that regulates cell growth. However, when the gene is mutated, …
The roles of KRAS in cancer metabolism, tumor ... - Springer
Jan 13, 2025 · In this review, we aim to summarize current knowledge on KRAS-related metabolic alterations in cancer cells and explore the prevalence and significance of KRAS mutation in shaping …
KRAS gene: MedlinePlus Genetics
The KRAS gene provides instructions for making a protein called K-Ras that is part of a signaling pathway known as the RAS/MAPK pathway. The protein relays signals from outside the cell to the …
Cracking KRAS | Amgen
Aug 25, 2025 · KRAS mutations are among the most common drivers of cancer. This mutation plays a major role in helping tumors grow and survive, especially in lung, colon and pancreatic cancers.